THE BMS-986141 DIARIES

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The composition from the unliganded double mutant HIV-1 RT confirmed that Lys103Asn mutation facilitates coordination of the sodium ion with Lys101 O, Asn103 N and O(delta1), Tyr188 O(eta), and two h2o molecules. The formation in the binding pocket requires the removal in the sodium ion. Even though the RT by itself and also the RT/HBY 097 advanced